CofC Logo

Timothy Barker

Assistant Professor

Address: SSMB 312
Phone: 843.953.7182


The Scripps Research Institute
NIH Postdoctoral Fellow, 2011-2013
Advisor: Dale Boger

University of California, Irvine
Ph.D. Organic Chemistry, 2011

Saint Olaf College
B.A. Chemistry, 2006









(14) Biaco, J. L.; Jones, S. L.; Barker, T. J. Lewis Acid-Catalyzed Borono-Minisci Reacons of Arylboronic Acids and Heterocycles. Heterocycles 2016, 92, 1687–1697.
(13) Jay, L. P.; Barker, T. J. Palladium-Catalyzed Synthesis of Allylic Ureas via an Isocyanate Intermediate. Eur. J. Org. Chem. 2016, 1829–1831.
(12) Guirgis, G. A.; Overby, J. O.; Barker, T. J.; Palmer, M. H.; Pate, B. H.; Seifert, N. A. The Molecular Structure of Methylfluoroisocyanato Silane: A Combined Microwave Spectral and Theoretical Study. J. Phys. Chem. A 2015, 119, 652658.
(11) Sears, J. E.; Barker, T. J.; Boger, D. L. Total Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4+2]/[3+2] Cycloaddition Cascade Initiated by an Allene Dienophile. Org. Lett. 2015, 17, 5460-5463.
(10) Barker, T. J.; Duncan, K. K.; Otrubova, K.; Boger, D. L. Potent Vinblastine C20′ Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line. ACS. Med. Chem. Lett. 2013, 4, 985–988.

 (9) Leggans, E. K.; Duncan, K. K.; Barker, T. J.; Schleicher, K. D.; Boger, D. L. A Remarkable Series of Vinblastine Analogues Displaying Enhanced Activity and an Unprecedented Tubulin Binding Steric Tolerance: C20′ Urea Derivatives. J. Med. Chem. 2013, 56, 628–639.

 (8) Barker, T. J.; Boger, D. L. Fe(III)/NaBH4-Mediated Free Radical Hydrofluorination of Unactivated Alkenes. J. Am. Chem. Soc. 2012, 134, 13588–13591.

 (7) Leggans, E. K.; Barker, T. J.; Duncan, K. K.; Boger, D. L. Iron(III)/NaBH4-Mediated Additions to Unactivated Alkenes: Synthesis of Novel 20′-Vinblastine Analogues. Org. Lett. 2012, 14, ASAP.

 (6)  Barker, T. J.; Jarvo, E. R.  Developments in Transition Metal-Catalyzed Reactions Using Electrophilic Nitrogen Sources. Synthesis 2011, 3954–3964.

 (5)  Barker, T. J.; Jarvo, E. R.  Titanium-Mediated Amination of Grignard Reagents using Primary and Secondary Amines. Angew. Chem. Int. Ed. 2011, 50, 8325–8328.

 (4)  Barker, T. J.; Jarvo, E. R.  Mechanistic Studies of Diene-Ligated Ir(I) Allylations of Ketones.  Synthesis 2010, 3259–3262.

 (3)  Barker, T.. J.; Jarvo, E. R.  Umpolung Amination of Diorganozinc Reagents with N,N-dialkyl-N-chloroamines. J. Am. Chem. Soc. 2009, 131, 15598–15599.

 (2)  Barker, T. J.; Jarvo, E. R.  Diene-Ligated Iridium Catalyst for Allylation Reactions of Ketones and Imines. Org. Lett. 2009, 11, 1047–1049.

 (1)  Gout, D.; Barker, T. J.; Gourdon, O.; Miller, G. J.  A New Superstructure for the BaAl4-Structure Type: An Experimental and Theoretical Study of La2NiAl7. Chem. Mat. 2005, 17, 3661–3667.