Michael Giuliano

Assistant Professor


Yale University
Postdoctoral Associate, 2011-2015
University of Wisconsin-Madison
Ph.D. Organic Chemistry, 2011
Villanova University
B.S. Chemistry, 2006

Research Interests

Structural characterization of signaling peptides via NMR and other biophysical techniques, peptide synthesis methods, development of oxidation-based synthetic methods for useful organic building blocks.

Courses Taught



8) Review: "Site-Selective Reactions with Peptide-Based Catalysts” Giuliano, M.W.; Miller, S.J. Top. Curr. Chem2015. In Press.

7) “A Synergistic Combinatorial and Chiroptical Study of Peptide Catalysts for Asymmetric Baeyer–Villiger Oxidation” Giuliano, M.W.; Lin, C.-Y.; Romney, D.K.; Anslyn, E.V.; Miller, S.J. Adv. Synth. Catal. 2015357, 2301-2309.

6) ) “Function-Oriented Investigations of a Peptide-Based Catalyst that Mediates Enantioselective Allylic Alcohol Epoxidation” Abascal, N.C.; Lichtor, P.A.; Giuliano, M.W.; Miller, S.J. Chem. Sci. 20145, 4504-4511. Note: designated as an “Edge Article”

5) "A gamma-Amino Acid that Favors 12/10-Helical Secondary Structure in alpha/gamma-Peptides.” Giuliano, M.W.; Maynard, S.J.; Almeida, A.M.; Guo, L.; Guzei, I.A.; Spencer, L.A.; Gellman, S.H. J. Am. Chem. Soc. 2014136, 15046-15053.

4) "Evaluation of a Cyclopentane-Based gamma-Amino Acid for the Ability to Promote alpha/gamma-Peptide Secondary Structure” Giuliano, M.W.; Maynard, S.J.; Almeida, A.M.; Reidenbach, A.G.*; Guo, L.; Ulrich, E.C.*; Guzei, I.A.; Gellman, S.H. J. Org. Chem201378, 12351-12361.              

            *undergraduate researchers

3) "Characteristic Structural Parameters for the gamma-Peptide 14-Helix: Importance of Subunit Preorganization” Guo, L.; Zhang, W.; Reidenbach, A.G.; Giuliano, M.W.; Guzei, I.A.; Spencer, L.C.; Gellman, S.H. Angew. Chem. Int. Ed201150, 5843-5846.

2) “Gamma Amino Acid Building Blocks” Gellman, S.H.; Guo, L.; Giuliano, M.W. U.S. Patent Application No. 20110118440, Filed October 14, 2010.

1) “An alpha/beta-Peptide Helix Bundle with a Pure beta3-Amino Acid Core and a Distinctive Quaternary Structure” Giuliano, M.W.; Horne, W.S.; Gellman, S.H.  J. Am. Chem. Soc. 2009131, 9860-9861. Note: highlighted in Nature Chemical Biology, 2009, 5, 614-615.